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Life sciences literature
Downloads: Life sciences
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Brochure: Biological analysis using Raman spectroscopy and imaging
The domain of biological research is shaped by our ability to peer into the world of the small. Simply seeing microscopic biological samples is useful, but by utilising Raman spectroscopy we can surpass sight into the molecular realm… and beyond! Download this brochure to discover the wealth of biological applications made possible by Renishaw's Raman systems.
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Notes d’applications : Biologie rédox avec le microscope Raman confocal inVia [it]
La spectroscopie Raman est sensible à la présence d’hémoprotéines et est idéale pour l’étude de la biologie rédox sans avoir à prévoir d’isolation ou de coloration. La rédox (oxydo-réduction) des hémoprotéines est étroitement liée aux fonctions des protéines (transport et stockage de l’oxygène, transport des électrons et inhibition des radicaux libres). En utilisant la spectroscopie Raman pour élucider les états de rédox au sein des systèmes biologiques, les chercheurs peuvent étudier la dynamique de rédox et ses effets sur la régulation de la santé et les maladies.
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Application note: Raman imaging for biological applications. No stains. No labels.
Raman spectroscopy is an information-rich, label-free, non-invasive imaging technique that is ideal for life sciences research. It uses laser light scattering to provide a chemical fingerprint at each point of the analysed area and identifies the molecules present in samples.
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Product note: Microplate mapping with Renishaw Raman system's
Renishaw’s microplate mapping package enables researchers to use Renishaw’s Raman spectroscopy products to rapidly and easily analyse material contained in microplates.
Downloads: life sciences (cells)
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Application note: Classification of brain glioma tumours using the Renishaw Biological Analyser
Demonstrating discrimination between diseased and healthy brain tissue using the Renishaw RA816 Biological Analyser.
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Application note: Cell imaging with the inVia confocal Raman microscope
With Renishaw’s inVia confocal Raman microscope you can identify and characterise samples to provide chemical, spatial and structural information on multiple types of molecule, without labelling. It provides rich, detailed, chemical images and highly specific data at high spatial resolution, making it ideal for studying cells.
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Application note: Surface enhanced Raman spectroscopy (SERS) imaging using the inVia confocal Raman microscope
Raman imaging is a powerful research tool for understanding the molecular composition, structure and distribution of different chemical species. Nano silver/gold colloids and roughened metallic substrates can be used to amplify the intensity of the Raman scattering of adsorbed molecules via SERS. This can increase the sensitivity and/or the specificity of the analysis. SERS imaging can be used to evaluate the efficacy of delivery of nanoparticles (NPs) into cells/animals. SERS measurement of labelled or surface-modified NPs can also be used for biosensing, multiplexing and theranostics.
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Application note: Raman imaging to reveal components and metabolites in wood cells and tissue
Analysing Scots pine wood using the inVia™ confocal Raman microscope, to reveal high-resolution details of structure and chemical composition.
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Portrait of a dying cell
The December 2015 issue of 'The Pathologist' featured an article describing how Raman spectroscopy is a non-invasive way of obtaining morphological and chemical information about cells that may lead to better cancer research.
Downloads: life sciences (tissues)
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Application note: Monitoring transdermal drug delivery in skin using the RA816 Biological Analyser
Confirming the presence of a topical compound in the epidermis and reticular dermis with high specificity and sensitivity.
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Application note: Classification of brain glioma tumours using the Renishaw Biological Analyser
Demonstrating discrimination between diseased and healthy brain tissue using the Renishaw RA816 Biological Analyser.
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Application note: Tissue imaging with the inVia Raman microscope
Raman tissue imaging is a unique method that can simultaneously describe the molecular composition and the distribution of multiple chemical species in tissues at a high spatial resolution, without labelling.
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Application note: Raman imaging to reveal components and metabolites in wood cells and tissue
Analysing Scots pine wood using the inVia™ confocal Raman microscope, to reveal high-resolution details of structure and chemical composition.
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Product note: Rayleigh imaging using the inVia™ confocal Raman microscope
Product note detailing how you can perform Rayleigh imaging on the inVia confocal Raman microscope.
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Application note: Virsa Raman analyser for in vivo studies
The Virsa™ Raman analyser is ideal for developing clinical applications of Raman spectroscopy. It is available with a clinically-ready fibre-optic probe developed in partnership with EmVision, leaders in medical fibre probes.
Webinar
You may also like to view our webinar - 'Resonance Raman spectroscopy for redox biology research'.
Application examples
We have also produced a range of application examples, including those below.
If you would like to find out more, please contact your local representative using the button below, quoting the relevant document reference.
Document reference | Description |
| AS013 | 3D imaging a glioma cell. Reveal information about cells with inVia and 3D imaging. |
| AS014 | 3D imaging rat spinal tissue. Reveal information about tissue with inVia and 3D imaging. In this example, the tissue components of rat spinal column are determined. |
| AS016 | 3D imaging of cell organelles. Reveal information about cells with inVia and 3D imaging. In this example, the size and position of organelles wihin a glioma cell are determined. |
| AS017 | Spermatozoon imaging. Reveal information about anatomical parts of organisms with inVia. In this example, the anatomical parts of a spermatozoon are determined. |
| AS024 | AFM and 3D Raman imaging of glioma cells. Reveal detailed and complementary information on the composition of glioma cells by atomic force microscopy (AFM) and inVia 3D Raman imaging. |
| AS025 | Fluoresence and 3D Raman imaging of cell organelles. Unravel detailed and complementary information on the composition of glioma cells using confocal 3D Raman and fluorescence imaging. |
| AS031 | Distinguish embryonic stem/carcinoma cell lines without labelling. In this example, label free embryonic stem cell (ESC) and embryonic carcinoma cell (ECC) cell lines were differentiated using StreamLine™ imaging and principal component analysis. |
| AS034 | Raman imaging of spermatozoa. Reveal anatomical and chemical in normal and abnormal cells with inVia. In this example, the anatomical parts of a phenotypically normal and a phenotypically abnormal spermatozoon are determined. |
| AS036 | Raman imaging of plant cell walls. Reveal the distribution and the relative thickness of plant cell walls and syringyl lignin using StreamLineHR imaging |
| AS037 | Raman imaging of engineered melanoma models. Engineered 3D composites can be used to study the biochemistry of tumours, such as melanoma, and to investigate the impact of drugs on disease models. The tumour's size, chemistry, and its invasion and chemical alteration to the neighbouring tissue, are typically assessed. |
| AS038 | Raman live cell imaging. Non-invasive live cell imaging |
| AS053 | Raman imaging to reveal the morphological and biomolecular features in apoptotic cells. Reveal the morphology in apoptotic cells using confocal StreamLineHR imaging |