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Chemical sciences literature
Downloads: chemical sciences (pharmaceuticals)
Brochure: Solutions for pharmaceutical analysis
Renishaw is a world leader in Raman spectroscopy instrumentation, with over 25 years’ experience supplying Raman systems to customers worldwide. We are a global company, with a worldwide network of scientists and engineers who are on-hand to provide you with expert product, applications and technical support. We understand the many challenges within pharmaceutical analysis and our flexible solutions have been designed with your needs in mind. Whether novice or expert, formulator or quality analyst, we have a system to meet your requirements.
Product note: RA802 Pharmaceutical Analyser
Designed exclusively for the pharmaceutical industry, the RA802 rapidly obtains detailed information on the distribution of chemical species.
Application note: New methods for determining content uniformity of formulations
Using the RA802 to monitor the uniformity of a drug product’s contents to ensure that the correct dose is delivered every time.
Application note: Study the stability of pharmaceutical formulations with Raman microscopy
Many pharmaceutical materials are highly sensitive to changes in temperature and humidity which can affect their crystalline structure. Knowing the stability of these polymorphs and hydrates, in different conditions, is critical to ensure products are safe, efficient and can be patent protected.
Application note: Investigate pharmaceutical solid dose products using the inVia confocal Raman microscope
With so many components and properties, determining the composition, domain size and distribution of patent-expired commercially available formulations is highly desirable. This information creates opportunities to replicate an existing product without the need for lengthy development and prohibitive costs.
Application note: Transmission Raman for monitoring pharmaceuticals
Whether at the research and development stage, or manufacturing, the inVia Raman microscope offers simple and fast transmission Raman analysis.
Application note: Combined chemical and particle distribution analysis of pharmaceutical powders
When formulating pharmaceuticals, it is important to understand the chemical composition and morphologies of the ingredients, as these can lead to changes in product performance. For example, active ingredient co-localisation and particle adhesion can affect the efficacy of formulation. This application note details how to use a Renishaw Raman system to conduct this type of analysis.
Application note: Using Raman spectroscopy to tackle polymorphism, an industry problem
This note looks at incidences of polymorphism in drug development including advantages and challenges.
Application note: Raman imaging for deformulating a transdermal patch
An application note detailing the RA802's ability to deformulate the make-up of a transdermal nicotine patch.
Application note: Rapid polymorph identification with the RA802 Pharmaceutical Analyser
Characterising the polymorphism of active pharmaceutical ingredients when developing a commercially viable product.
Technical note: Quantitative Raman spectroscopy
This document focuses on concentration measurements but the principles detailed are also applicable to other quantitative measurements, such as stress/strain.
White paper: Finding fakes – using Raman imaging to identify counterfeit medicines
Raman spectroscopy is highly specific and well-suited to identifying counterfeits which often use similar components to the reference product.
White paper: Methods for deformulating drugs
In this white paper we look at reverse engineering existing drug products using Raman imaging. We show that the Renishaw RA802 Pharmaceutical Analyser can be used to successfully characterise innovator and generic products and facilitate deformulation activities, and can characterise the components, concentrations, particle sizes and distributions of the innovator formulation, allowing generic followers to adjust their processes in order to create equivalent products, or products which are strategically different.
Technical note: Polymorph identification and qualification
This technology note illustrates the benefits of combining dedicated analysis software with a high-performance Raman instrument and how Renishaw supplies an effective, user-friendly solution to provide complementary information to the multitude of established HTS techniques commercially available.
Application note: Detecting small amounts of multiple API polymorphic forms in powder blends
The stability, bioavailability and processability of an active pharmaceutical ingredient (API) are key to a candidate molecule’s ability to be developed into a commercially viable product. Different drug polymorphs can vary markedly in properties such as their flowability, dissolution rate, solubility, and stability. Characterising the different polymorphic forms of a drug and selecting the optimum polymorph for drug product development have become important considerations in this process. Renishaw’s RA802 Pharmaceutical Analyser was used to detect small amounts of different polymorphic forms (form I and form II) of an active pharmaceutical ingredient (API) in a generic drug powder.
Downloads: chemical sciences (polymers)
Application note: Analysing microplastics with the inVia™ confocal Raman microscope
Plastics are extensively used in products and packaging and, unfortunately, make their way into the environment, causing significant issues for wildlife. In addition to concerns about bulk plastic contamination, there has been much interest in microplastics. Raman spectroscopy, an optical scattering technique, has much to offer researchers investigating plastics, as it can identify them rapidly and non-destructively.
Application note: Study polymers with the inVia confocal Raman microscope
The Renishaw inVia confocal Raman microscope is ideal for the 2D and 3D chemical analysis of polymers. Synthetic polymers display a broad range of properties and are extensively used in modern products. The study of polymers in terms of identification, spatial distribution and concentration is important as we search for novel materials, improve effectiveness of existing materials, and reduce the costs of products. The inVia microscope provides chemical specificity and sensitivity, in a non-destructive manner, with no sample manipulation and preparation required.
Technical note: Using the inVia Raman microscope for locating and characterising microplastics
Renishaw’s inVia confocal Raman microscope is ideally suited to the analysis of microplastics. A combination of optical and Raman imaging techniques with Renishaw's WiRE software are used to locate, image and characterise particles.
Application note: Analysis of polymer fibres using the Virsa™ Raman analyser
Application note detailing how the Virsa Raman analyser can be used to analyse polymer fibres.
Downloads: chemical sciences (chemicals)
Application note: Study emulsions using the inVia confocal Raman microscope
The Renishaw inVia confocal Raman microscope is the ideal system for the complete 2D and 3D chemical analysis of emulsions and colloids.
Application note: Analyse coatings with the inVia™ confocal Raman microscope
Chemically characterise your coatings with Renishaw’s inVia confocal Raman microscope. It is the ultimate system for studies ranging from fundamental research on the materials involved through to final product quality control and failure analysis.
Application note: Analysing liquids with the Virsa™ Raman analyser
Application note showing how easy it is to analyse liquids with the Virsa Raman analyser
Application note: Monitoring phase changes
Monitoring the crystallographic phase changes of potassium nitrate using the inVia Raman microscope
Downloads: chemical sciences (catalysis)
Application note: Analysing catalytic powders with the Virsa™ Raman analyser
Application note detailing how the Virsa Raman analyser can be used to study catalysts, with vanadium oxide as an example.
StreamHR Rapide - nasal spray
Using a Renishaw inVia confocal Raman microscope and WiRE™ software to image a drop of nasal medication. The image build up is shown at true data collection speed using StreamHR Rapide.
We have also produced a range of application examples, including the following.
If you would like to find out more, please contact your local representative using the button below, quoting the relevant document reference.
Imaging detergent powder
Reveal information about powder mixtures with inVia and StreamLine imaging. In this example, single component domains and their distribution are quantified from a large powder area.
Imaging a pharmaceutical tablet
Reveal information about pharmaceutical formulations with inVia and StreamLine imaging. In this example, active pharmaceutical ingredient (API) domains and their distributions are quantified from an entire tablet section.
Imaging inhaler constituents
Reveal information about pharmaceutical formulations with inVia and StreamLine imaging. In this example, inhaler active pharmaceutical ingredients (API's) are identified and their relative locations compared.
Imaging coated nasal spray particles
Reveal information about pharmaceutical formulations with inVia and StreamLine imaging. In this example, nasal spray particles are identified, with the active pharmaceutical ingredient (API) being shown to coat the excipient carrier paritcle.
3D imaging a polymer laminate
Reveal information about multi-layered polymer films with inVia and 3D imaging.
Imaging Pirinase nasal spray
Reveal information about pharmaceutical formulations with inVia and StreamLine imaging. In this example, API domains and their distribution are quantified from a Pirinase droplet.
Analysing LA modes in polyethyleneReveal low wavenumber Raman bands with inVia. Here, the longitudinal acoustic mode (LAM) of high density polyethylene is shown.
Analysing lattice modes in sulfur
Reveal low wavenumber Raman bands with inVia. Here, the lattice modes (LAM) of sulfur are observed.
Analysing rotational modes of gases
Reveal low wavenumber Raman bands with inVia. Here, the rotational modes of atmospheric air bands are observed.
Analysing the composition of Piriton in high definition
This case study reveals the composition of an entire tablet in high definition with inVia.
Low wavenumber Raman imaging
Low wavenumber Raman bands contain important chemical and structural information. Traditionally low wavenumber Raman bands are observed using spectrometers with triple diffraction gratings, which do not provide sufficient Raman throughput to make imaging feasible. Renishaw's range of Eclipse filters for inVia make imaging of low wavenumber Raman bands easy.
Quantifying the composition of a SINGULAIR® tablet in high definition
Improve the accuracy of quantifying active pharmaceutical ingredient (API) domain sizes and amounts using inVia's high definition StreamLine™ imaging. SINGULAIR® (generically known as montelukast sodium) is a medication used to improve symptoms of asthma and allergic rhinitis. In this example, the SINGULAIR® API domains are quantified and compared. Different spatial resolution images show the benefit of generating large, high definition data.
Confocal Raman imaging of yogurt
Raman imaging of yoghurt can provide information on its protein-lipid network, the packing order of lipids and hydration, without employing any stains.